Why IVF Fails- Top 21 Reasons For Failed IVF - Fertilityworld Book An Appointment
Why IVF fails

In vitro fertilization, or IVF, is among the most innovative and ground-breaking advancements in the field of reproductive treatments. IVF provides infertile couples a glimpse of hope, a chance at motherhood that would otherwise be out of reach. There is no doubt that IVF is a treatment that has changed many lives by letting people realize their ambition of having their own biological children.

Despite the excitement and hope that IVF inspires, it is important to recognise that treatment is not always successful. Unfortunately, the journey of many optimistic parents’ end in a failed IVF. Each unsuccessful effort may cause an agonizing emotional rollercoaster, and the concerns that follow are frequently significant.

Video Credit- Natalie Crawford, MD

In this in-depth blog by Fertility World, we dive into the core of unsuccessful IVF as well as its astounding importance of coping strategies after unsuccessful reproductive therapy. We set out on a trip to comprehend complexities of IVF and maybe more importantly—the failed IVF reasons. Why does IVF occasionally fail to provide the intended results despite advances in reproductive science?

Our goal at Fertility World is to highlight the top 21 causes of IVF failure. Understanding these underlying causes may perhaps bring comfort, understanding, and eventually a fresh feeling of hope to people who are going through IVF. Let’s get started by exploring the subject of IVF failure symptoms and the numerous factors that could result in its unanticipated disappointments.

IVF Failure Symptoms

It might be frustrating and perplexing when an IVF round doesn’t provide the desired outcomes. Knowing the possible signs of IVF failure will help you make sense of the situation and direct your course of action. Here are some typical IVF failure symptoms:

  1. Negative Pregnancy Test

Negative pregnancy test results during the prescribed waiting period are one of the most obvious indicators of failed IVF. Negative results, which indicate that an IVF round did not produce a pregnancy, can be emotionally heartbreaking. It’s essential to control expectations and get ready for unforeseen setbacks.

  1. Lack of symptoms of pregnancy

Not experiencing early pregnancy signs like nausea, tiredness, or swollen breasts. The lack of these signs might indicate a failed IVF round. However, this is not a certain signal because not all women exhibit these symptoms.

  1. Abnormal Bleeding

Abnormal or irregular bleeding that resembles a long period. This can indicate a failed IVF cycle. It suggests that fertilization might not have happened exactly as planned.

  1. Pelvic Pain

Persistent pelvic discomfort or soreness following embryo transfer. While some little cramping is expected, prolonged or severe discomfort may be a sign that something went wrong during the operation or with the embryo implantation.

  1. Sudden Changes in Hormones

A rapid shift in hormone levels is frequently found through blood testing. Hormonal abnormalities that hinder embryo implantation might cause unsuccessful IVF.

  1. Mental Anxiety

Overwhelming anxiety, despair, or emotional anguish. Managing the psychological effects of unsuccessful IVF can be an issue in and of itself. It’s critical to look for assistance and expert advice from specialists such as those at Fertility World, during this trying period.

  1. Weariness

The physical difficulties of therapy mixed with the psychological impact of IVF might result in greater weariness.

  1. Difficulty Coping

Failed  IVF may be indicated by feelings of helplessness or difficulty managing day-to-day tasks. If necessary, get assistance from family members or a mental wellness professional.

  1. Increased Stress

Your general well-being might suffer as a result of the stress of reproductive treatments. Be aware of elevated stress levels and engage in stress-reduction activities.

  1. Effect on Relationships

IVF failure may put a burden on relationships, leading to tension and communication problems. It’s essential to have frank conversations with your partner.

  1. Loss of Sexual Interest

Your desire for sexual closeness may become momentarily disinterested due to emotional changes or physical pain.

It’s crucial to remember that each situation is different, therefore exhibiting any one of these signs does not always mean that the attempt will lead to a failed IVF. To discuss your particular circumstances and look into probable causes for a failed IVF cycle, speak with your fertility doctor.

Top 21 Reasons for Failed IVF

The grief of a failed IVF effort might occur when the path to parenthood through in vitro fertilization (IVF) occasionally takes unforeseen twists.  By addressing these failed IVF reasons, we seek to empower individuals and couples to face the IVF experience head-on and with resiliency.  Let’s examine the top 21 causes of unsuccessful IVF to shed insight into the intricate network of variables that might impact this procedure.

  • Embryo Genetic Abnormalities

Genetic abnormalities in embryos are considered to be the most frequent causes of IVF failure. Such abnormalities may stop the embryo from growing normally, which might result in unsuccessful implantation or a premature miscarriage. Genetic problems can result from deviations from the egg or the sperm, both, of which increase the risk of implantation failure or miscarriage. Advanced techniques of genetic testing are used to detect abnormalities in chromosomes before transferring the embryos, improving the likelihood of choosing healthy ones, especially for people with a record of chromosome anomalies or recurrent attempts of unsuccessful IVF attempts

  • Implanting Problems

IVF failures can occur when embryos don’t adequately connect to the endometrial lining. This may happen as a result of complications with the developing embryo or problems with the uterine environment. Implantation failure may be caused by immunological issues, inadequate thickness of the endometrium,  or hormonal abnormalities.  Hormone-based drugs and procedures like Intrauterine insemination are frequently employed to address these problems and increase the possibility of successful implantation.

  • Endometriosis

When endometriosis occurs, tissue that resembles the uterine lining develops outside the uterus. IVF success and fertility may be affected by the resulting inflammation and scarring. Endometriosis patients may have a diminished ovarian reserve, poor-quality eggs, and a greater chance of unsuccessful implantation. To remove endometriotic tissue, a laparoscopic excision, which is a surgical process, may be advantageous for certain people, increasing their chances of success with IVF.

  • Obstetrical anomalies

Unsuccessful IVF might occur as a result of abnormalities in the uterus structure preventing embryo implantation. Problems such as fibroids in the womb, or polyps, might alter the woman’s reproductive environment or provide physical challenges. To increase the success rates of IVF, surgical procedures or hysteroscopy may be required to rectify certain problems.

  • Age Factor

Failed IVF is significantly influenced by advanced mother age. Less healthy eggs are frequently produced by older women, which increases the possibility of unsuccessful fertilisation or aberrant embryo development. Additionally, the responsiveness of the lining of the uterine cavity may provide difficulties for elderly women. Egg donors can be suggested in certain circumstances in order to increase the likelihood of being pregnant successfully. By inserting the healthy sperm directly in the egg by the method of ICSI, or intracytoplasmic sperm injection, these problems can be targeted.

  • Issue Relating to Sperm

 Male infertility issues can also be one of the causes of IVF failure. Fertilisation can be hampered by low sperm counts, sluggish sperm motion, or defective sperm morphology. This issue can also be addressed by utilizing  ICSI.

  • Ovulatory Issues

IVF treatments that don’t work might be caused by ovulation that is irregular or lack of ovulation, known as anovulation. To manage ovulation and increase the likelihood that IVF will be successful, ovarian stimulation (COS) regimens or oocyte-inducing drugs may be used.

  • Endometrial lining that is thin

Sometimes women’s uterine linings might be too thin, which can make it difficult for embryos to effectively implant. IVF success rates can be raised by employing techniques including prolonged oestrogen supplementation, greater monitoring, and strategic timing of embryo transfer.

  • Lifestyle elements

The results of IVF might be negatively impacted by lifestyle decisions including smoking, binge drinking, or being obese. These elements may impair the quality of the egg and sperm, lessen the likelihood of embryo implantation, and result in unsuccessful IVF. Choosing a better lifestyle and reaching an acceptable weight can increase the likelihood that an IVF cycle will be successful.

  • Emotional and stressor factors

The results of IVF might be impacted by elevated anxiety and mental anguish. Hormone abnormalities brought on by stress might impact ovulation and fertilization. Individuals may be better able to handle the emotional components of IVF and may increase success rates by engaging in stress-reduction strategies, counseling, or support groups.

  • Insufficient Ovarian Reaction

A small amount of collected eggs may be the outcome of an inadequate reaction to ovarian stimulation in certain women during IVF. This may lower the likelihood of getting healthy embryos for a transfer. In such circumstances, modifying the stimulation of ovaries strategy or taking into account different possibilities, such as normal IVF or donation eggs, may be advised.

  • The LUFS (Luteinized Unruptured Follicle Syndrome)

When the follicle that is dominant fails to expel eggs at ovulation despite hormonal stimuli, this condition is known as LUFS. Due to the lack of eggs available for retrieval, this might result in unsuccessful IVF rounds. To deal with this problem, careful observation and possible modifications to the induction of ovulation procedures may be required.

  • Thyroid Conditions

IVF success and thyroid abnormalities including hypothyroidism and hyperthyroidism are correlated. The likelihood of a good IVF outcome can be increased by maintaining optimum thyroid functioning with medication and routine monitoring.

  • Insufficient Support for Progesterone

For the lining of the uterus and early pregnancy, sufficient levels of progesterone are essential. In the luteal phase, low progesterone supplementation might result in early miscarriage or implantation failure. Individualized supplementation of progesterone can be utilized depending on specific needs.

  • Ovarian tumors

By blocking the ovaries or altering hormone production, big ovarian cysts might hinder the usual IVF procedure. Before IVF, surgical excision of these cysts may be required to improve treatment results.

  • Hydrosalpinx

IVF success rates might suffer from hydrosalpinx, or fallopian tubes packed with fluid. Such tubes may prevent implantation of embryos or result in the leakage of toxic materials into the uterus. Procedures like tubal blockage or surgical removal may enhance IVF results.

  • Biological Elements

Sometimes an overactive immune system might result in embryo rejection causing IVF to fail. For patients with suspected immunological problems, immune-modulating therapies such intralipid treatment or immunosuppressive drugs may be taken into consideration.

  • Infections

Infertility and IVF success might be hampered by undiagnosed infections within the reproductive systems. To provide an optimal endometrial atmosphere for the implantation of embryos during IVF, it is essential to treat any existing infections before the procedure.

  • Medicine-Related Problems

The quality of the embryos produced through the IVF cycle might be affected by incorrect drug doses or timing. To avoid these problems, meticulous medication adherence and close monitoring are necessary.

  • Environmental Toxins

IVF results can be impacted by exposure to environmental chemicals and pollution, which can lower the quality of eggs and sperm. Adopting a healthy lifestyle and reducing exposure to such pollutants will increase the chances of successful IVF.

  • Low-Quality Eggs or Sperm

Infertility treatment failures might be caused by insufficient egg or sperm quality. In order to overcome this difficulty, advanced reproductive procedures including the use of donated eggs or sperm may be advised.

There are many causes of IVF failure, and it’s critical to properly address each one through a customized strategy. In order to pinpoint the precise reasons why IVF treatments fail and create individualized treatment regimens that will increase the likelihood of a successful pregnancy, fertility specialists at Fertility World, carefully collaborate with both individuals and couples.

Coping Strategies After a Failed IVF Cycle

The period after failed IVF can be extremely challenging. Being able to deal with dissatisfaction, annoyance, and sadness is crucial. Let these coping techniques assist you during the period after failed IVF:

  • It’s OK to grieve: After a failed IVF effort, it’s perfectly normal to have a feeling of loss. Permitting oneself to be sad, angry and upset is important and is necessary for healing.
  • Get Support: Lean on your spouse, your family, and others for emotional assistance. Sharing emotions with a supportive person may bring about a great deal of relief.
  • Care Groups: Think about signing up for online forums or support groups where you may talk to people who have gone through similar difficulties. It might be reassuring to exchange tips and experiences.
  • Expert Assistance: A counselor who has experience with reproductive problems can provide advice and coping mechanisms that are suitable for you. You can develop resilience and process difficult emotions with the aid of therapy.
  • Self-Care: To promote your physical and mental well-being, put an emphasis on caring for yourself. Whether it’s yoga, meditation, or following a hobby, do anything that makes you happy and relaxed.
  • No More Blame: Don’t blame your partner or yourself for unsuccessful IVF. Keep in mind that a variety of circumstances, seldom just you, influence the results of infertility.
  • Create reasonable expectations: Recognise that no one cycle of IVF is certain to be successful. Setting reasonable expectations might help to lessen the emotional toll that disappointments take.
  • Take a Break: If you’re feeling overburdened in the period after failed IVF, think about stopping fertility treatments. A break might give you time to emotionally recover and think about your next move.
  • Consider Other Routes: Talk to your doctor about alternative fertility therapies or methods. An alternative course of treatment could work in certain cases.
  • Future Plans: Remember that the quest for fertility is continuous. Pay attention to your long-term objectives and the procedures necessary to attain them. Each cycle advances you closer to your ultimate objective.
  • Speak for self: Seek answers, get second perspectives, and consider all your alternatives without holding back and supporting your own journey.

Keep in mind that every person’s reproductive journey is different and that recovery takes patience. Be kind to yourself and put your mental health first.


It’s critical to keep in mind that you don’t feel alone in the complicated and often emotional period after failed IVF. Even if your path has its share of challenges, many people can relate to the difficulties you’ve faced and the aspirations that kept you motivated.

There is no universal approach to fertility since it is a highly individual journey. On your path, you could experience happiness, optimism, indeed, sadness and despair. But keep in mind that every step you take will get you nearer to your objective.

There always exists faith, whether you are just starting out on your reproductive journey or have encountered setbacks due to failed IVF. Reproductive healthcare developments provide new opportunities and paths to achievement.

Additionally, becoming parents in the future is still an option, with Fertility World. With more than 300 clinics spanning across the globe, Fertility World is committed to assisting people and couples in growing their families. We provide cutting-edge therapies including innovative IVF technologies, surrogacy services and genetic tests

Our cutting-edge labs are outfitted with the most recent technologies. Our goal is to help couples realize their desire to have children by utilizing technology for assisted reproduction. Regardless of their background, we feel that every dream of parenthood should be fulfilled. Consistent dedication to excellence, from technology to care, delivering the greatest results, is what makes Fertility World unique.

Get a Free Consultation

Your submission is received and we will contact you soon