Today, infertility has prevented many people from getting pregnant. Although some infertility factors have been studied many are unexplained. In-vitro fertilization (IVF) is such an amazing assisted reproductive technology (ART) that overcomes many problems and in return hands out the parenthood possibility at an affordable cost. The fertilityworld has set up its top 10 best IVF clinics in the world working with some of the world’s top infertility specialists.
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What is In-vitro fertilization?
In-vitro fertilization or IVF is an assisted fertility treatment that involves superovulation, egg removal, and assisted fertilization of the eggs and the sperm in the embryology laboratory. The embryologist transfers the fertilized egg/embryos into the female uterus which leads to In-vitro fertilization pregnancy. The advancement of In-vitro fertilization (IVF) technology has highly navigated infertile patients worldwide ensuring their parenthood dreams.
In-vitro fertilization cost/IVF injection cost
Globally, In-vitro fertilization costs vary from one country to another. Compared to the IVF cost worldwide, IVF is expensive in all Western countries with an average of 25,000 USD per cycle. In contrast, IVF cost is lower in Asian countries and India is the only Asian country that offers a reasonable IVF cost of 4500 USD per self-cycle to 6500 per donor-cycle. There is also an opportunity available for couples to pay the IVF cost in different stages, for more details; visit here: Everything you need to know about IVF price. The table below represents the IVF cost breakup offered by the fertilityworld.
| Payment break-up | Payment Schedule |
| 1st Payment | At the time of IVF registration |
| 2nd Payment | During the egg retrieval |
| 3rd Payment | At the time of embryo creation |
| 4th and last payment | After embryo transfer is done. |
IVF injections majorly comprise 3 variants, stimulant, suppressant, and embryo glue. These IVF injection costs also vary and are comparatively higher in Western countries than in Asian countries. Asian countries like India are the best IVF destinations because IVF treatment and IVF injection costs are quite affordable. The cost of a stimulant IVF injection is 840 USD, suppressant IVF injection is 25 USD, and embryo glue IVF injection is 120 USD.
What is the process of in-vitro fertilization (IVF)?
The process of in-vitro fertilization (IVF) includes; receiving a free consultation from experts either online/offline, visiting the clinic as scheduled (during a periodical cycle), undergoing pre-fertility screening for both partners, medication, and then comes the main part, medical IVF procedure stages such as superovulation that produces multiple eggs, egg/oocyte removal by the embryologist, collection of the semen sample, combination of eggs and sperms for fertilization to occur, then the transfer of the embryo into the uterus. Through blood work and ultrasound, the transferred embryo is monitored until pregnancy is confirmed. A complete IVF cycle usually takes about 6-8 weeks. The mother normally carries the pregnancy to term (9 months) and delivers the baby under the supervision of the specialists.
In-vitro fertilization (IVF) success rate
The In-vitro fertilization (IVF) success rate is up to 75% in the self-cycle to 85% in the donor cycle, it can reach as high as 95% when IVF is performed at the right age, right time, and at the right IVF clinic. The IVF success rate can also be enhanced with advanced procedures like ICSI and the use of donor eggs. According to IVF Doctors, a higher success rate is obtainable in women in the age group of 21 to 35 years for they have good quality eggs. The success rate is extendable even to older age when they approach top specialists and receive medical attention. You can analyze the IVF success rate table below:
What are the 5 stages of in-vitro fertilization (IVF)?
The 5 stages of in-vitro fertilization (IVF) include
Stage 1. Superovulation (Production of multiple eggs)
Women normally release 1 egg per month but IVF needs multiple eggs. For this reason, hormonal medications or injections are prescribed for some days, which stimulate the follicles to produce multiple eggs. More egg production ensures better chances of successful IVF. Also, hormonal injection is given for eggs to mature.
Stage 2. Retrieving/removing the eggs
Once the eggs attain maturity, they are retrieved by the embryologist through a minor surgical procedure known as follicular aspiration.
Stage 3. Collection of sperm sample
At the time of egg removal, your partner or donor is asked to provide the sperm sample. Mostly, they provide the sperm through the traditional way (masturbation) or surgical sperm aspiration procedures like TESA, PESA, etc if your partner has a low sperm count or has not ejaculated.
Stage 4. Combine the eggs and sperm
Immediately after the eggs and sperm collection. They are inoculated into the Petri dishes under the culture medium to achieve fertilization with the resultant called the embryo. This step is referred to as artificial insemination. The embryologist may also inject sperm directly into the egg known as intracytoplasmic sperm injection (ICSI).
Stage 5. Transfer the embryo into the uterus
After 3 to 5 days of fertilization, the top-quality embryo is picked and loaded into the catheter by the doctor and then transferred into the uterus in the hope of achieving a successful pregnancy. The embryo implantation into the uterus usually follows the traditional ways of conceiving pregnancy to term.
In-vitro fertilization-embryo transfer process
The In-vitro fertilization-embryo transferring process is crucial for IVF success. In this process, anesthesia or sedation is rarely used. The best stage embryo of the agreed-upon number is loaded in a long, thin catheter along with a small amount of fluid. A catheter is passed through the cervix into the uterus, where the embryo or embryos are released using ultrasound guidance for best placement.
What are the types and techniques of in-vitro fertilization (IVF)?
Usually, IVF treatment is classified into two types: self-cycle IVF and donor-cycle IVF. Let us understand them in detail below
1. Self-cycle IVF
It refers to the IVF treatment using a self-egg and self-sperm that creates an embryo. This type of IVF is done for couples having compatible eggs and sperm and who are unable to conceive through natural sexual intercourse due to certain infertility factors including fallopian tube problems, tubal sterilization, ectopic pregnancy, miscarriages, or males with weak sperm mobility or poor sperm morphology.
2. Donor-cycle IVF
It refers to the IVF treatment using donor assistance either the donor egg or the donor sperm. The use of donor eggs becomes the best option for women with poor ovarian reserve or diminished ovarian reserve. The use of Donor sperm is best for those male with no sperm count. The process and procedure are the same as the one explained above except the eggs/sperm preparation procedure is done in the donors.
The techniques of in-vitro fertilization (IVF) are:
- The generation of several numbers of eggs by hormonal drugs.
- The aspiration of eggs from the follicles using special needles under ultrasound guidance.
- Culturing the eggs and sperm in the media from the laboratory to achieve fertilization (outside the human body).
- Placement of the embryo in the uterus technically using a catheter.
- Achieve pregnancy like all fertile women.
IVF pregnancy risk
Very rarely, IVF shows a minimal pregnancy risk. Patients can experience IVF pregnancy risk can enhance the likelihood of twins, and triplets, with accompanying risk for premature birth, high blood pressure, placenta abnormalities, gestational diabetes mellitus, prematurity, and other challenges like. Hypertension-related complications can affect the mother and the fetus. IVF pregnancy risks also include early labor and delivery, low birth weight, miscarriage, and birth defects.
IVF Baby disadvantage
Mostly, IVF babies are as normal as other children when compared to their physical attributes and mental capacity. They are as naturally born as other children. However, IVF babies might have some slight disadvantages including, the baby being born with heart issues, digestive problems, or other conditions such as low birth weight, premature birth, fetal growth restriction, imprinting disorders, congenital birth defects, and neonatal death.
In-vitro fertilization (IVF) steps and process
In-vitro fertilization (IVF) treatment involves 5 steps and processes:
Step 1: Fertility Medication or Hormonal drugs
This step helps a woman to produce 8 to 10 eggs rather than 1 egg in a normal month.
Step 2: Harvest the eggs
The boosted multiple eggs are aspirated from the follicles in this step.
Step 3: Fertilization
The third step is to achieve fertilization of the egg by the partner’s sperm.
Step 4: Embryo culture
Step four is culturing and monitoring the embryo division to secure the best-growth embryo.
Step 5: Embryo transfer
The fifth step of in vitro fertilization is the embryo is transferred to the female uterus by the embryologist using special equipment.
Who is applying for IVF treatment?
IVF treatment has become the best pathway for infertile couples suffering from different reproductive barrier factors, genetic disorders, transmittable diseases, and exposure to different lifestyles causing infertility, and because of individual situations. However, most couples who are applying for IVF treatments have shown the following reasons below:
- Aging women with fertility issues,
- Right-age women between 21-35 years with fertility issues,
- Women with low ovarian reserve, poor egg quality,
- Women with blocked or damaged fallopian tubes,
- Males with low sperm count or blockages,
- Women with tubal ligation/sterilization.
Your expectations behind the IVF treatment
A complete IVF cycle takes hardly 6-8 weeks from start to finish including the medication period and procedures. Many people think that IVF treatment is painful and difficult. However, the procedure is simple and painless. Of course, one can experience irritation due to egg retrieval procedures and embryo transfer procedures in the uterus but such irritations and dizziness will disappear after a few days of the procedure.
How many IVF injections can you expect?
Usually, 3 types of IVF injections you can expect but they are administered by looking at your reproductive responses. These IVF injections include
- Stimulation injection, to stimulate multiple egg development.
- Suppressing injection, to suppress ovulation from occurring.
- Embryo Glue injection to support the process of implantation & higher chances of conception.
Factors that are affecting the IVF cost
The IVF cost is inclusive of all the IVF processes and procedures required in a single cycle which includes consultations, medications, injections, healthcare, IVF procedures (ovulation, retrieving, fertilization, and childbirth), and donor cost if applied.
Some factors that can affect the IVF cost include;
- Standard procedures like ICSI when IVF fertilization fails.
- Additional treatments in case of female endometriosis, and fibroids. Treating them can avoid IVF ectopic pregnancy or miscarriages. The cost is charged separately for the procedure.
- Repeating the IVF cycle involves additional costs although not the inclusive cost.
- In some clinics, doctor’s fees, laboratory charges, and additional healthcare services might include separate costs.
IVF baby advantages
- IVF babies resemble parents in self-cycle.
- More healthier than your expectations.
- 100% biological in a self-cycle baby.
- 50% biological in donor-cycle babies.
- IVF babies are just as intelligent as others.
- Physically fit as their naturally conceived counterparts.
- The IQ of an IVF baby is an average of 112, and the naturally born baby’s average IQ is 107.
- Summing up; the IVF baby is physically, and mentally fit like normal children.
Top 10 best IVF clinics in the world
The fertilityworld IVF Center is among the top 10 best IVF clinics in the world today. It has established the highest IVF success rates around the world in cities like Dubai | Bangkok | New Delhi | Mumbai | Georgia, Tbilisi| Kenya | Malaysia | the Philippines, And Nepal. The centre has a dedicated team of fertility Doctors who have been strictly scrutinized and carefully selected based on their extensive regional & international experience in the field of infertility, and reproductive medicine, and speaking a multitude of languages which creates a balancing chain considering patients from any originality.
Conclusion: IVF treatment
IVF treatment is highly recommended for couples with build-in confidence to receive parenthood. It may seem like a myth but it highly favors those infertile people with a distinct mentality because fertility medication and treatments require stress-free and healthy reproductive organs to reproduce. IVF is an amazing technology paving the way for desperate infertile people to conceive a baby. The technology and the techniques surrounding IVF treatment are renewed every day ensuring a guaranteed success rate.
