IVF PROCESS STEP BY STEP

In-vitro fertilization (IVF) is the most advanced successful infertility treatment for all infertile couples and single parents. The IVF procedure is very simple and follows an orderly IVF process step by step. In pan India, the fertilityworld is the best in formulating simple IVF procedures that produce the highest success rates.  

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Available infertility treatments and services

There are various infertility treatments available today but the most demanding and most successful infertility treatments are mentioned below respectively by the fertilityworld:

• Intrauterine Insemination (IUI),

• In-vitro fertilization (IVF)- self-cycle/Donor-cycle
• Intracytoplasmic sperm injection (ICSI),
• Frozen embryo transfer (FET),
• Laser-assisted hatching (LAH),
• Semen analysis testing,
• Surgical sperm aspiration,
• Hysteroscopy & Laparoscopy,
• Services: Donor Assistance (egg, sperm, & embryo), Fertilization, Child delivery, etc.

Highest IVF success rates

The highest IVF success rates in India are 75% in Self-cycle and 85% in Donor-cycle IVF. The fertilityworld infertility specialist team has concluded that the most excellent IVF success rate is seen among women between 21-35 years of age because this age group mostly has good-quality eggs which are crucial for the IVF success rate. But when that woman crosses over 35 years, her egg quality declines gradually which also adds to infertility complications including endometriosis, obesity, miscarriages, recurrent pregnancy, etc. However, with proper medical attention from the expert, women above 35 can still have a successful IVF treatment. Let’s look at the IVF success rate chart of the fertilityworld in pan India:

Comprehensive information on IVF step-by-step

The term In-Vitro Fertilization means fertilization of the egg and sperm outside the body, medically by growing them in Petri dishes under culture media inside the fertility laboratory, then implantation of the fertilized egg into the woman’s uterus (womb), completing within 3 weeks time. Let’s look at the detailed IVF process step by step: 

IVF Process step by step:

1. Initial consultation: At fertilityworld, the patient is provided with free consultation. This step determines whether IVF can favor you or not.

2. Ovulation: After the initial menstrual cycle, the ovulation or superovulation (release of the egg from the ovary) begins by giving fertility medication/IVF injections including FSH or LH  hormones. These hormones boost the body and enhance multiple egg production than normal. The more eggs produced, the more chances of successful fertilization later in the treatment. Transvaginal ultrasounds and blood tests are done regularly during this step, it checks ovaries and monitors the hormone levels.

3. Trigger Injection: After successful ovulation, the right time to administer the trigger injection (hCG) is scheduled, this will aid the egg’s final maturation and loosen it from the follicle wall. This trigger injection-specific time is crucial.

4. Egg retrieval/pickup: The egg retrieval takes place on the 2nd morning after the final trigger injection (34-36 hours later). The embryologist will perform a minor surgical procedure known as the follicular aspiration to retrieve the eggs or “egg-pick up” under very light sedation. An ultrasound-guided probe guides the fine needle into each ovary through the vaginal canal. This fine needle attached to the suction mechanics sucks out the egg, one at a time. The fluid in the follicle is then extracted into a test tube and studied under a microscope to look for eggs. This procedure takes about 20 to 30 minutes, depending on the number of follicles that have developed. This step is performed as an outpatient.

5. Semen Sample Collection: While the eggs are being retrieved, a male partner is asked to produce his semen sample through traditional methods or via surgical sperm aspirations. It may be possible to produce the sample at home and drop it off at the clinic, or freeze his semen samples as a backup. Patients can also choose to use donor sperm (if required). The sperm are then put through a high-speed wash and spin cycle to find the healthiest ones.

6. Fertilization: The best-concentrated sperm is combined with the retrieved eggs and cultured in Petri dishes under the culture medium called insemination. Then, the eggs are kept in an incubator overnight and examined the next day for signs of fertilization. Mostly, 60-70% of eggs get fertilized, if the sperm sample appears normal. The fertilized eggs are then kept in the incubator for 48 hours for complete mature development. In some cases, IVF specialists may suggest an ICSI procedure, if the sperm quality is low (low sperm count, morphology, or motility). ICSI is a specialized form of treatment for male infertility that involves injecting a single sperm directly into a single mature egg.

7. Embryo Transfer: The transferring of the embryo begins about 2-5 days after fertilization. The chosen best-stage embryo is placed into a thin plastic catheter (a soft tube), that passes through the cervix, into the uterus, and gently releases the embryo which is known as the IVF implantation process in India. Generally, Multiple embryos are transferred in the hopes that at least one will implant itself in the lining of the uterus and begin to develop. Sometimes more than one embryo ends up implanting, which is why multiples are possible in women who use IVF. The process itself takes only a few minutes and is usually painless. This part of the IVF process is performed in the doctor’s office while you are awake. After the transfer, some of the remaining embryos may be suitable for vitrification (rapid freezing), and this option is available to all patients undergoing IVF treatment. Frozen embryos can be used in subsequent cycles if the first one is not successful. 

8. The luteal phase: This is the phase/time between the embryo transfer and the pregnancy test. During this time, the patient must look after herself and maintain good health and well-being. The IVF process replicates natural reproduction. 

9. Pregnancy confirmation test: After 14 days of the embryo transfer, a pregnancy confirmation test is done through a blood test, ultrasound, etc. If pregnancy is confirmed, a mother will be the first person to be notified and suggest the next follow-up steps to take on your journey to having a child. We recognize that the time between embryo transfer and pregnancy test can be emotionally charged with anxiety and expectations. Therefore, the fertilityworld can arrange a place to give birth, parting our happiness with your expanding family. We provide personalized, compassionate care and will support you at every step of your fertility journey.

Outcomes of the IVF treatment

• If your pregnancy is confirmed: You will be referred to an obstetrician or other pregnancy specialist for prenatal care at the fertilityworld team. 
• If your pregnancy is unconfirmed: you’ll stop taking progesterone and likely get your period within a week. If you don’t get your period or you have unusual bleeding, contact our doctor. If you’re interested in attempting another cycle of in vitro fertilization (IVF), our doctor will suggest steps you can take to improve your chances of getting pregnant through IVF. However, most patients achieve IVF in the 1st cycle except due to some major infertility factors.

How long does the IVF process take from start to finish?

A complete IVF process cycle will usually take about 6 weeks to 8 weeks. The complete IVF process includes an initial consultation, ovarian stimulation (8-14 days), egg retrieval, fertilization, embryo transfer, and a pregnancy test. The embryo transfer and pregnancy test are typically performed 5 days after fertilization.

Advantages of IVF treatments

IVF is the most advanced infertility treatment with high demand for its highest benefits like normal pregnancy and delivery:

• IVF assures the highest success rate of pregnancy,
• It totally helps both men and women to overcome infertility problems,
• It ensures lesser chances of miscarriage,
• IVF is open to anyone either young or old,
• IVF allows untreatable infertile parents to use donated Eggs/Sperm,
• Prospective parents can schedule their convenient time to undergo IVF treatment,
• IVF improves 90% chances of having a healthy baby.

What factors can decide the successful IVF process?

The following factors decide the successful IVF process step by step:

• Age of the female partner
• Duration of infertility
• Type of infertility (primary or secondary)
• Cause of infertility
• Quality of the sperm, egg, and embryo
• The endometrial development
• Luteal phase post-transfer

What is the cost of IVF treatment?

The most affordable IVF cost is offered by the fertilityworld in pan India. Two types of IVF treatment costs, one is self-cycle IVF treatment at Rs.1.50 lakhs and the second is donor-cycle IVF treatment at Rs 2.20 lakhs. The process is the same in both cases, the difference is the use of gametes (self or donor). The inclusive cost is transparent and flexible, it covers all the IVF process and other procedures including

• Fertility screenings & tests before IVF,
• Ovarian stimulation (if IVF is a self then infertile mother, if the donor then female donor), 
• Egg retrieval cost and embryologist fees,
• Cost of fertilization of egg and sperm in the lab,
• Embryology laboratory charges,
• The fertilized embryo transferring cost, 
• Cost of IVF implantation process in India,
• Pregnancy confirmation test charges,
• Childbirth arrangement charges (if requested). 

Most of the couple achieves successful IVF either in the 1st or the 2nd IVF cycle. And for every repeating IVF cycle, the patients have to pay Rs. 50,000 more because every cycle creates a fresh new embryo that supports IVF pregnancy.

The table shown below represents the most affordable IVF cost in pan India:

Who needs IVF treatment?

• A couple who have failed IUI treatment,
• Women with blocked or damaged fallopian tubes
• Women below 45 years with unexplained infertility,
• Women with damaged or blocked fallopian tubes,

• Women with endometriosis
• Males with low sperm counts or tube blockage 
• Males with high numbers of sperm in abnormal shape or movement. 
• Women with ovulation disorders,
• Female with endometriosis- affecting the function of the ovaries, uterus, and fallopian tubes.
• Uterine fibroids common in women in their 30s and 40s- interfere with the implantation of the fertilized egg.
• Previous tubal sterilization or removal
• Unexplained infertility (no cause of infertility despite evaluation for common causes).
• Couples with a genetic disorder,
• Fertility preservation for cancer or other health conditions.

The best age for women to succeed in IVF process treatment

IVF is most successful for women in their 20’s and early 30’s, numerically grouping between 21-35 years. The IVF success rates steadily get reduced when women cross over 35 years. A woman’s age and years of infertility become the deciding factor in IVF treatment.

Why choose the fertilityworld for IVF treatment?

The fertilityworld is 25 years old since it was established and is considered the oldest and the most successful in IVF treatment in pan India. The centre has got a strong reputation for producing the highest IVF success rates at the most affordable IVF cost. The fertilityworld has the largest chain of fertility networks around the world. It provides unexceptional environments in terms of infrastructure, friendly Doctors, and staff. The fertilityworld teams merely deal in cost but mostly in fulfilling the parenthood dreams of many. They help, guide, and stand with the patients until and unless they receive a child through fertility treatments.

Dr Souren Bhattacharjee